Sum1p, the origin recognition complex, and the spreading of a promoter-specific repressor in Saccharomyces cerevisiae.

@article{Lynch2005Sum1pTO,
  title={Sum1p, the origin recognition complex, and the spreading of a promoter-specific repressor in Saccharomyces cerevisiae.},
  author={Patrick J Lynch and H. B. Fraser and Elena Sevastopoulos and Jasper Rine and Laura N. Rusch{\'e}},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 14},
  pages={5920-32}
}
In Saccharomyces cerevisiae, Sum1p is a promoter-specific repressor. A single amino acid change generates the mutant Sum1-1p, which causes regional silencing at new loci where wild-type Sum1p does not act. Thus, Sum1-1p is a model for understanding how the spreading of repressive chromatin is regulated. When wild-type Sum1p was targeted to a locus where mutant Sum1-1p spreads, wild-type Sum1p did not spread as efficiently as mutant Sum1-1p did, despite being in the same genomic context. Thus… CONTINUE READING