Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae.

@article{Xie1999Sum1AH,
  title={Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae.},
  author={Jianxin Xie and Michael Pierce and Val{\'e}rie Gailus-Durner and Marisa Wagner and Edward Winter and Andrew K. Vershon},
  journal={The EMBO journal},
  year={1999},
  volume={18 22},
  pages={6448-54}
}
Meiotic development in yeast is characterized by the sequential induction of temporally distinct classes of genes. Genes that are induced at the middle stages of the pathway share a promoter element, termed the middle sporulation element (MSE), which interacts with the Ndt80 transcriptional activator. We have found that a subclass of MSEs are strong repressor sites during mitosis. SUM1 and HST1, genes previously associated with transcriptional silencing, are required for MSE-mediated repression… CONTINUE READING
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