Sulthiame but not levetiracetam exerts neurotoxic effect in the developing rat brain

@article{Manthey2005SulthiameBN,
  title={Sulthiame but not levetiracetam exerts neurotoxic effect in the developing rat brain},
  author={Daniela Manthey and Stella Asimiadou and Vanya Stefovska and Angela M. Kaindl and Jessica Fassbender and Chrysanthy Ikonomidou and Petra Bittigau},
  journal={Experimental Neurology},
  year={2005},
  volume={193},
  pages={497-503}
}
Antiepileptic drugs (AEDs) used to treat seizures in pregnant women, infants, and young children can cause cognitive impairment. One mechanism implicated in the development of neurocognitive deficits is a pathologic enhancement of physiologically occurring apoptotic neuronal death in the developing brain. We investigated whether the newer antiepileptic drug levetiracetam (LEV) and the older antiepileptic drug sulthiame (SUL) have neurotoxic properties in the developing rat brain. SUL… 
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TLDR
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Antiepileptic drugs and brain development
Epilepsy, the most common neurological disorder in young humans, has its highest incidence during the first year of life. Antiepileptic drugs (AEDs) which are used to treat seizures in infants,
Long‐term antiepileptic drug administration during early life inhibits hippocampal neurogenesis in the developing brain
Certain antiepileptic drugs (AEDs) that are commonly used to treat seizures in children also affect cognition, and these effects can persist into adulthood, long after drug withdrawal. Widespread
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It is found that levetiracetam may cause severe developmental abnormalities, and is likely not safe for use in pregnant women, and the risk increased still further when both drugs were administered in combination.
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