Sulpiride versus Haloperidol, a Clinical Trial in Schizophrenia. A preliminary report

@article{MunkAndersen1984SulpirideVH,
  title={Sulpiride versus Haloperidol, a Clinical Trial in Schizophrenia. A preliminary report},
  author={E. Munk‐Andersen and Kirsten Behnke and Jon Heltberg and H Nielsen and Jes Gerlach},
  journal={Acta Psychiatrica Scandinavica},
  year={1984},
  volume={69}
}
Abstract Sixteen out of 25 hebephrenic and paranoid schizophrenic patients completed a double‐blind cross‐over study with sulpiride and haloperidol. The patient sample was relatively chronic: Median age was 35 years (range 26–53 years), median duration of illness 10 years (4–35 years), and median duration of neuroleptic treatment 5 years (1–28 years). Each patient was treated with sulpiride/haloperidol in random order for 12 weeks with a drug‐free period before each treatment phase. 
20 Citations

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In a survey of the best maintenance doses of neuroleptics in schizophrenics, Baldessarini and Davis (1980) did not find a dose-effect relationship among dose equivalents of about 100–2500 mg chlorpromazine per day.

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Sulpiride: an Antipsychotic with Selective Dopaminergic Antagonist Properties

A unique pharmacology does not appear to provide sulpiride with a greater effectiveness than the standard antipsychotics, but may provide it with minor safety advantages.

A Risk-Benefit Assessment of Sulpiride in the Treatment of Schizophrenia

Sulpiride could find its specific therapeutic role in elderly patients with schizophrenia, as it shows a good margin of safety between therapeutic dosages and toxic concentrations, and its low incidence of extrapyramidal adverse effects.

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Melperone is potent in blocking amphetamine induced locomotion, exploratory behaviour, L‐Dopa induced jumping and aggression suggesting a limbic mode of action and a weak effect of melperone on striatal DA neurotransmission.

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