Sulpiride and perphenazine in schizophrenia

  title={Sulpiride and perphenazine in schizophrenia},
  author={Ulla M. Lepola and Teuvo Koskinen and Ranan Rim{\'o}n and H Salo and Ariel Gordin},
  journal={Acta Psychiatrica Scandinavica},
Seventeen patients with acute schizophrenia and 30 with chronic schizophrenia were included in a randomized, double‐blind parallel‐group trial comparing sulpiride and perphenazine. Patients were evaluated using the 16‐item Brief Psychiatric Rating Scale (BPRS) prior to the onset of treatment and 1 and 2 weeks, and 1, 2, 3, and 4 months thereafter. In patients with acute schizophrenia, total BPRS scores declined significantly at the end of the trial compared with pretreatment values in sulpiride… 

Sulpiride augmentation in people with schizophrenia partially responsive to clozapine

A subgroup of patients with chronic schizophrenia may substantially benefit from sulpiride addition to clozapine, and exhibited substantially greater and significant improvements in positive and negative psychotic symptoms.

Sulpiride augmentation of olanzapine in the management of treatment-resistant chronic schizophrenia: evidence for improvement of mood symptomatology

Improvement in depressive symptomatology with sulpiride augmentation of olanzapine in treatment-resistant chronic schizophrenia patients is indicated.

A Risk-Benefit Assessment of Sulpiride in the Treatment of Schizophrenia

Sulpiride could find its specific therapeutic role in elderly patients with schizophrenia, as it shows a good margin of safety between therapeutic dosages and toxic concentrations, and its low incidence of extrapyramidal adverse effects.

Sulpiride for schizophrenia.

Sulpiride may be an effective antipsychotic drug but evidence is limited and data relating to claims for its value against negative symptoms is not trial-based.

Sulpiride: an Antipsychotic with Selective Dopaminergic Antagonist Properties

A unique pharmacology does not appear to provide sulpiride with a greater effectiveness than the standard antipsychotics, but may provide it with minor safety advantages.

Levosulpiride: a review of its clinical use in psychiatry.

Risks of Sulpiride-Induced Parkinsonism in Peptic Ulcer and Gastroesophageal Reflux Disease Patients in Taiwan: A Nationwide Population-Based Study

At the population level, sulpiride may be frequently prescribed and apparently effective for PUD and GERD patients, but SIP is associated with older age, hypertension, depression or anxiety comorbidities.


From the available literature, no histological studies dealing with the effect of experimentally-induced hypcrprolactinerniu on the neurons of the hypothalamic nuclei or the pituitary gland were previously done.



[Study of the clinical effects of sulpiride and perphenazine in 82 schizophrenic patients by the double blind method].

Using "Armitage's Restricted Sequential Design", there was no significant difference between the therapeutic effects of these 2 neuroleptics, however, Sulpiride appeared more beneficial following the review during the 8th week and the 4th week.

Clinical Evaluation of Sulpiride in Schizophrenic Patients ‐ A Double‐blind Comparison with Chlorpromazine

A double‐blind study was performed comparing fixed doses of sulpiride and chlorpromazine for the treatment of schizophrenic patients, and interrater reliabilities for CPRS items and subscales were satisfactory.

Controlled Trial of Sulpiride in Chronic Schizophrenic Patients

The results show that sulpiride has neuroleptic properties and a spectrum of therapeutic activity similar to that of trifluoperazine.

Sulpiride and Haloperidol in Schizophrenia: A Double-blind Cross-over Study of Therapeutic Effect, Side Effects and Plasma Concentrations

In a double-blind cross-over trial, 20 chronic schizophrenic patients treated with sulpiride and haloperidol in two 12-week periods, no correlation could be established between clinical effects and plasma levels of either neuroleptic.

[Schedule for Affective Disorders and Schizophrenia (SADS)].

This article represents the French translation of the Schedule for Affective Disorders and Schizophrenia (SADS), developed by researchers at the New York State Psychiatric Institute and Columbia

Comparison of sulpiride and chlorpromazine in psychoses

In a material of 71 patients admitted because of acute or chronic psychoses, 32 patients treated with sulpiride and 39 with chlorpromazine, the effect of the two preparations was very similar as were the type and frequency of side effects, except that sulpirides did not cause sunrash.


The central action of sulpiride differs from that of classic neuroleptics in that this drug stimulates dopamine turnover without producing catalepsy.

The Brief Psychiatric Rating Scale

A substantial, specific abnormality in CSPG expression by astrocytes is pointed out that may contribute disruption of the function of neurones and glial cells of the amygdala and the entorhinal cortex in schizophrenia.

Dopaminteorin i aktuell belysning

Fran grundforskningshall ar det viktigt att betona att det inte bara finns en, utan tva olika dopamin-(DA) teorier. Dels teorin att den symptomkontrollerande effekten av antipsy-kotiskt verksamma