Sulpiride and perphenazine in schizophrenia

@article{Lepola1989SulpirideAP,
  title={Sulpiride and perphenazine in schizophrenia},
  author={Ulla M. Lepola and Teuvo Koskinen and Ranan Rim{\'o}n and H Salo and Ariel Gordin},
  journal={Acta Psychiatrica Scandinavica},
  year={1989},
  volume={80}
}
Seventeen patients with acute schizophrenia and 30 with chronic schizophrenia were included in a randomized, double‐blind parallel‐group trial comparing sulpiride and perphenazine. Patients were evaluated using the 16‐item Brief Psychiatric Rating Scale (BPRS) prior to the onset of treatment and 1 and 2 weeks, and 1, 2, 3, and 4 months thereafter. In patients with acute schizophrenia, total BPRS scores declined significantly at the end of the trial compared with pretreatment values in sulpiride… 

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Dopaminteorin i aktuell belysning

Fran grundforskningshall ar det viktigt att betona att det inte bara finns en, utan tva olika dopamin-(DA) teorier. Dels teorin att den symptomkontrollerande effekten av antipsy-kotiskt verksamma