Sulpiride and Haloperidol in Schizophrenia: A Double-blind Cross-over Study of Therapeutic Effect, Side Effects and Plasma Concentrations

@article{Gerlach1985SulpirideAH,
  title={Sulpiride and Haloperidol in Schizophrenia: A Double-blind Cross-over Study of Therapeutic Effect, Side Effects and Plasma Concentrations},
  author={Jes Gerlach and Kirsten Behnke and Jon Heltberg and E. Munk‐Andersen and Henrik Nielsen},
  journal={British Journal of Psychiatry},
  year={1985},
  volume={147},
  pages={283 - 288}
}
Summary In a double-blind cross-over trial, 20 chronic schizophrenic patients were treated with sulpiride and haloperidol in two 12-week periods. The final median dose of sulpiride was 2000 mg/day (range 800–3200) and of haloperidol 12 mg/day (range 6–24). Sulpiride had an antipsychotic effect and therapeutic profile not significantly different from that of haloperidol. In spite of the high doses of sulpiride, extrapyramidal side-effects were seen less frequently during the first four weeks of… 
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77 Citations
Background Citations
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Methods Citations
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Results Citations
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77 Citations

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Neuroleptic treatment induces region-specific changes in levels of neurokinin a and substance P in rat brain

Dopamine D-2 antagonists reverse apomorphine-induced decreased water intake in the rat: prediction of antipsychotic drugs with few extrapyramidal side-effects?

  • T. Ljungberg
  • Psychology, Medicine
    Journal of Neural Transmission
  • 2005
The model described may be used in screening experiments aimed at finding new antipsychotic drugs with a low incidence of EPS, and can be explained by the existence of two subpopulations of D-2 receptors related to different functions.
...

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