Sulphonylurea action revisited: the post-cloning era

  title={Sulphonylurea action revisited: the post-cloning era},
  author={Dr. F. M. Gribble and Frank Reimann},
Hypoglycaemic agents such as sulphonylureas and the newer group of "glinides" stimulate insulin secretion by closing ATP-sensitive potassium (KATP) channels in pancreatic beta cells, but have varying cross-reactivity with related channels in extrapancreatic tissues such as heart, vascular smooth and skeletal muscle. Experiments on the structure-function relationships of recombinant KATP channels and the phenotypes of mice deficient in different KATP channel subunits have provided important… CONTINUE READING
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