Sulphide quinone reductase contributes to hydrogen sulphide metabolism in murine peripheral tissues but not in the CNS.

@article{Linden2012SulphideQR,
  title={Sulphide quinone reductase contributes to hydrogen sulphide metabolism in murine peripheral tissues but not in the CNS.},
  author={D R Linden and Julie K. Furne and Gary J Stoltz and Mohamed Saber Abdel-Rehim and Michael D. Levitt and Joseph H. Szurszewski},
  journal={British journal of pharmacology},
  year={2012},
  volume={165 7},
  pages={2178-90}
}
BACKGROUND AND PURPOSE Hydrogen sulphide (H(2) S) is gaining acceptance as a gaseous signal molecule. However, mechanisms regarding signal termination are not understood. We used stigmatellin and antimycin A, inhibitors of sulphide quinone reductase (SQR), to test the hypothesis that the catabolism of H(2) S involves SQR. EXPERIMENTAL APPROACH H(2) S production and consumption were determined in living and intact mouse brain, liver and colonic muscularis externa using gas chromatography and… CONTINUE READING
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