Sulphatide and sulphatide antibodies in insulin-dependent diabetes mellitus.

  title={Sulphatide and sulphatide antibodies in insulin-dependent diabetes mellitus.},
  author={Karsten Buschard and Knud Josefsen and Thomas Horn and Pam Fredman},
  volume={342 8875},
Insulin-dependent diabetes mellitus (IDDM) is associated with neurological disorders. Sulph I, a monoclonal antibody to sulphatide (a neural epitope), stained secretory granules in alpha and beta cells of rat islets of Langerhans, but not exocrine tissue. Sera from 88% of 57 newly diagnosed IDDM patients was anti-sulphatide positive, and 76% were positive 6 months later. All 135 healthy controls were negative. Sulphatide antibody may be an IDDM marker. 

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