Sulphadiazine-resistance in Plasmodium gallinaceum and its relation to other antimalarial compounds

  title={Sulphadiazine-resistance in Plasmodium gallinaceum and its relation to other antimalarial compounds},
  author={Ann Bishop and Elspeth W. McConnachie},
  pages={163 - 174}
1. A thirty-two-fold increase in resistance to sulphadiazine has been induced in Plasmodium gallinaceum in chicks by treatment with that drug. 2. No loss in resistance to sulphadiazine occurred in the resistant strain during cyclical passage through Aëdes aegypti. 3. The sulphadiazine-resistant strain was resistant also to sulphathiazole, sulphanilamide and sulphapyridine, but not to mepacrine, quinine or pamaquin. An increase in sensitivity to pamaquin was observed. 4. The sulphadiazine… 
31 Citations

Resistance to primaquine in Plasmodium gallinaceum, and the problem of resistance to quinoline compounds in malaria parasites

A tenfold enhancement of resistance to primaquine was obtained by maintaining a strain of Plasmodium gallinaceum in a state of acute infection by serial passage of infected blood through young chicks

Resistance to primaquine in Plasmodium gallinaceum , and the problem of resistance to quinoline compounds in malaria parasites

The following account describes the development of a primaquine-resistant strain of P. gallinaceum, its stability, and the effect of other antimalarial drugs upon it; it also describes attempts to produce resistance to chloroquine in this species and discusses the general problem of resistance to aminoquinolines in malaria parasites.

Pamaquin Resistance in a Strain of Plasmodium gallinaceum and its relationship to Other antimalarial Drugs

A four- to eight-fold increase in resistance to pamaquin has been developed in a strain of Plasmodium gallinaceum in chicks, and an appreciable loss in resistance was observed after it had been maintained in the absence of the drug for a period of 6 months.

Resistance to diamino-diphenylsulphone in Plasmodium gallinaceum

A fourfold enhancement of resistance to diamino-diphenylsulphone has been produced over a period of 15 months in strain A of P. gallinaceum by subjecting the strain, maintained in a state of patent

The chemotherapy of Plasmodium berghei. I. Resistance to drugs.

1. Strains of P. berghei resistant to sulphadiazine, pyrimethamine, and methylene blue were produced by treating acute infections with low doses of drug. 2. The strain resistant to methylene blue was

Latent infections in avian malaria in relation to the production of drug-resistance

The failure to obtain resistant strains of malaria by prolonged treatment of latent infections with large amounts of drug, lends support to the theory of the origin of resistant strainsof malaria by the selection of resistant mutants.

The development of resistance to metachloridine in Plasmodium gallinaceum in Chicks

1. An increase in resistance to metachloridine of more than 100-fold was obtained within a few weeks in a strain of Plasmodium gallinaceum treated with gradually increasing doses of the drug and

Partial Inhibition by Mepacrine of the Development of Sulphonamide Resistance in Plasmodium berghei

It is explored whether the simultaneous administration of mepacrine and a sulphonamide in malaria would result in any change in the pattern of development of resistance of the parasites to either drug.

The chemotherapy of Plasmodium berghei. II. Antagonism of the action of drugs

The action of pyrimethamine, sulphadiazine, proguanil and its active metabolite CPT, and 2:4-diaminopteridines against infections of Plasmodium berghei in mice was antagonized by P–aminobenzoic acid

The action of 2:4-diamino-6:7-diisopropylpteridine upon Plasmodium gallinaceum and its relation to other compounds which are pteroylglutamic acid antagonists

Two strains of Plasmodium gallinaceum were made resistant to 2:4-diamino-6:7-diisopropylpteridine (0/129) by treatment with that drug, and in one strain treated with 0/129, the development of resistance to that drug itself preceded resistance to proguanil, and resistance to PROGuanil preceded resis tance to pyrimethamine.



Drug-resistance in Plasmodium gallinaceum, and the persistence of paludrine-resistance after mosquito transmission

Chickscarrying a latent infection of the normal strain of P. gallinaceum were immune to infection with the paludrine-resistant strain; and conversely chicks carrying a latent infections of the palUDrine- resistant strain were immune with the normal parasite.

Inhibition of Antimalarial Action of Sulfonamides by p-Amino-benzoic Acid

The effect of p-aminobenzoic acid in inhibiting the action of sulfanilamide against plasmodia is reported, which is thought to be essential to the organism.

Prophylactic and Curative Effects of Certain Sulfonamide Compounds on Exoerythroeytic Stages in Plasmodium Gallinaceum Malaria.

The fact that exoerythrocytic stages of Plasmodium gallinaceum respond so readily to some of the sulfonamide compounds and yet are totally refractory to quinine or atebrin furnish another lead in the study of malarial chemotherapy.

The action of antimalarial drugs in mosquitoes infected with Plasmodium gallinaceum.

For the purposes of this study, a prophylactic drug in the vertebrate host is defined as one which, when administered for a specific interval, permanently interrupts the pre-erythrocytic development of the parasite and prevents the formation of the erythroCytic forms.

The Effectiveness of Two New Types of Chemotherapeutic Agents in Malaria: Sodium P,P'-Diaminodiphenylsulfone N,N'-Didextrosesulfonate (Promin) and 2-Sulfanilamido Pyrimidine (Sulfadiazine).

Ten years of experience in attempting to control malaria in a number of endemic areas in Panama leaves the impression that it is quite impossible to eradicate malaria parasites by these means or reduce them to a point where transmission is greatly reduced.

Effects of Paludrine and Other Antimalarials

THE facility with which pathogenic protozoa and A bacteria may acquire resistance to therapeutic agents, as a result of non-curative treatment of infections by these pathogens, is of profound

The testing of drugs against exoerythrocytic forms of P. gallinaceum in tissue culture.

  • I. M. Tonkin
  • Biology, Medicine
    British journal of pharmacology and chemotherapy
  • 1946
In 1938 James and Tate described a tissue phase of P. gallinaceum in chicks which they called the exoerythrocytic phase of the parasite, and in 1945 Hawking succeeded in growing these forms in tissue

Acquired Resistance to Paludrine in Plasmodium Gallinaceum

Acquired Resistance and Persistence after Passage through the Mosquito