Sulodexide modifies intravascular homeostasis what affects function of the endothelium.

@article{Poubiska2013SulodexideMI,
  title={Sulodexide modifies intravascular homeostasis what affects function of the endothelium.},
  author={Alicja Połubińska and Ryszard Staniszewski and Ewa Baum and Katarzyna Sumińska-Jasińska and Andrzej Bręborowicz},
  journal={Advances in medical sciences},
  year={2013},
  volume={58 2},
  pages={
          304-10
        }
}
PURPOSE Sulodexide is a mixture of heparin and dermatan sulphate which has an antithrombotic action. It was shown that it has also direct effect on the endothelial cells. We tested the effect of sulodexide on the intravascular homeostasis in patients with peripheral vascular disease. METHODS Sulodexide was infused iv. at a dose of 1200 Lipoprotein Lipase Releasing Units (LRU) in 10 patients with peripheral vascular disease. Blood samples were collected before the infusion and 1, 6 and 24… 
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N-Acetylcysteine and Sulodexide Reduce the Prothrombotic Effect of Uremic Serum on the Venous Endothelial Cells
TLDR
Uremic serum induces prothrombotic changes in VEC, which may cause a predisposition to thrombosis disorders in patients with renal failure, which suggests their potential therapeutic application in uremic patients.
Sulodexide promotes arterial relaxation via endothelium-dependent nitric oxide-mediated pathway.
Comparative Anticoagulant and Thrombin Generation Inhibitory Profile of Heparin, Sulodexide and Its Components
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TLDR
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TLDR
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The blood pressure lowering potential of sulodexide--a systematic review and meta-analysis.
TLDR
The data suggest that sulodexide treatment results in a significant BP reduction, especially in hypertensive subjects, and indicates that endothelial glycosaminoglycans might be an independent therapy target in cardiovascular disease.
Use of sulodexide for the treatment of disorders of peripheral microcirculation in patients with systemic sclerosis
TLDR
Sulodexide is a safe rheological drug successfully used to treat a number of diseases accompanied by microcirculation disorders, including scleroderma, and seems to be a good and safe drug worth recommending.
Soluble syndecan-1 and glycosaminoglycans in preeclamptic and normotensive pregnancies
TLDR
The results show that an interplay between syndecan-1 and dermatan sulphate contributes to sFlt1 induced blood pressure elevation in pre-eclampsia.
Sodium-induced changes of the endothelial surface layer and microcirculation
TLDR
It is proposed that sodium-associated microcirculatory changes might explain the - not yet clarified - link between sodium and high blood pressure and sulodexide, a mixture of constituents of the endothelial surface layer, might be a new interesting drug to lower blood pressure.
Sulodexide in the treatment of patients with early stages of COVID-19: a randomised controlled trial
TLDR
Early intervention in COVID-19 patients with sulodexide reduced hospital admissions and oxygen support requirements, making sulodExide a favorable medication until an effective vaccine or an antiviral becomes available.
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