Sulindac. Trials of a new anti-inflammatory drug.

@article{Huskisson1978SulindacTO,
  title={Sulindac. Trials of a new anti-inflammatory drug.},
  author={Edward C Huskisson and Jane Scott},
  journal={Annals of the rheumatic diseases},
  year={1978},
  volume={37 1},
  pages={89-92}
}
Trials in patients with rheumatoid arthritis and osteoarthritis showed sulindac to be an analgesic with anti-inflammatory properties and at least as effective as aspirin. It was effective within 24 hours in doses of 300-400 mg daily. It had the advantages of twice daily administration and a lower incidence of gastric side effects than aspirin. Constipation, usually mild, occurred in 20-30% of cases. Like other anti-inflammatory drugs, it was effective in only a proportion of the patients. 

References

Publications referenced by this paper.
Showing 1-9 of 9 references

A double blind multiclinic trial of sulindac in the treatment of ankylosing spondylitis

  • M. R. Liebling, R. D. Altman, +11 authors R. F. Wilkens
  • Arthritis and Rheumatism
  • 1975

Experiences during double-blind study with MK-231 versus indomethacin in patients suffering from ankylosing spondylitis

  • F. W. J. Gribnau, D. A. Lissone
  • Nederlands Tifdschrift voor
  • 1975

Clinoril in acute gout

  • M. I. Khoury, C. J. Smyth
  • Acta Rheumatologica Portuguesa,
  • 1974

A double - blind crossover trial of aspirin , indomethacin and phenylbutazone in ankylosing spondylitis

  • R. G. Godfrey, J. J. Calabro, D. Mills, B. A. Maltz
  • Arthritis and Rheumatism
  • 1972

A double-blind crossover trial of aspirin, indomethacin and phenylbutazone in ankylosing spondylitis. Arthritis

  • R. G. Godfrey, J. J. Calabro, D. Mills, B. A. Maltz
  • 1972
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