Sulindac. A potentially renal-sparing nonsteroidal anti-inflammatory drug.

  title={Sulindac. A potentially renal-sparing nonsteroidal anti-inflammatory drug.},
  author={R D Bunning and Werner F. Barth},
  volume={248 21},
Three patients experienced rapidly reversible azotemia related to the use of naproxen or ibuprofen but tolerated full-dose sulindac. This article discusses renal toxicity of nonsteroidal anti-inflammatory drugs (NSAIDs), with emphasis on the role of inhibition of prostaglandin synthesis, and reviews evidence supporting a renal-sparing property of sulindac. The current literature assumes that all NSAIDs possess a similar potential for renal toxicity. The data presented suggest that sulindac has… CONTINUE READING


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