Sulindac Enhances the Killing of Cancer Cells Exposed to Oxidative Stress

@article{Marchetti2009SulindacET,
  title={Sulindac Enhances the Killing of Cancer Cells Exposed to Oxidative Stress},
  author={Maria Cristina Marchetti and Lionel Resnick and Edna Gamliel and Shailaja Kesaraju and Herbert Weissbach and David M. Binninger},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={232 - 235}
}
BACKGROUND Sulindac is an FDA-approved non-steroidal anti-inflammatory drug (NSAID) that affects prostaglandin production by inhibiting cyclooxygenases (COX) 1 and 2. Sulindac has also been of interest for more than decade as a chemopreventive for adenomatous colorectal polyps and colon cancer. PRINCIPAL FINDINGS Pretreatment of human colon and lung cancer cells with sulindac enhances killing by an oxidizing agent such as tert-butyl hydroperoxide (TBHP) or hydrogen peroxide. This effect does… CONTINUE READING