Sulfur mustard induces apoptosis in cultured normal human airway epithelial cells: evidence of a dominant caspase-8-mediated pathway and differential cellular responses.

Abstract

We have shown that sulfur mustard (SM; bis-(2-chloroethyl) sulfide), an alkylating, vesicating chemical warfare agent, causes dermal toxicity, including skin microblisters, via the induction of both death receptor (DR) and mitochondrial pathways of apoptosis in human epidermal keratinocytes. While SM is known for its skin-vesicating properties, respiratory… (More)

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@article{Ray2008SulfurMI, title={Sulfur mustard induces apoptosis in cultured normal human airway epithelial cells: evidence of a dominant caspase-8-mediated pathway and differential cellular responses.}, author={Radharaman Ray and Brian M. Keyser and Betty J. Benton and Ahmad Abou Daher and Cynthia Marie Simbulan-Rosenthal and Dean S. Rosenthal}, journal={Drug and chemical toxicology}, year={2008}, volume={31 1}, pages={137-48} }