Sulfur-directed enantioselective synthesis of functionalized dihydropyrans.

  title={Sulfur-directed enantioselective synthesis of functionalized dihydropyrans.},
  author={Roberto Fern{\'a}ndez de la Pradilla and Mariola Tortosa and Nadia Lwoff and Miguel A del {\'A}guila and Alma Viso},
  journal={The Journal of organic chemistry},
  volume={73 17},
The highly selective base-promoted cyclization of enantiopure sulfinyl dienols affords allylic sulfinyl dihydropyrans. The scope of this methodology, including the preparation of seven-membered rings, has been studied in depth. The reactivity of our sulfinyl dihydropyrans toward oxidation, imination, and dihydroxylation has been explored, and thus several routes to densely functionalized pyran derivatives have been outlined. The reactivity of allylic dihydropyranyl sulfones and sulfoximines in… 
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