Sulfur dioxide derivatives increase a hyperpolarization-activated inward current in dorsal root ganglion neurons.

@article{Du2007SulfurDD,
  title={Sulfur dioxide derivatives increase a hyperpolarization-activated inward current in dorsal root ganglion neurons.},
  author={Zhengqing Du and Yufen Zhou and Pin Yang},
  journal={Toxicology},
  year={2007},
  volume={239 3},
  pages={180-5}
}
The effect of derivatives of sulfur dioxide (SO(2)), a common air pollutant, which exists in vivo at equilibrium between bisulfate and sulfite, was studied on hyperpolarization-activated cation current (I(h)) in cultured post-natal dorsal root ganglion (DRG) neurons using the whole cell configuration of patch-clamp technique. SO(2) derivatives increased I(h) current in a dose and voltage-dependent manner. The EC(50) value was 25 microM and the Hill coefficient was 1.44. 50 microM SO(2… CONTINUE READING

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