Sulfur-containing amino acids block stretch-dependent K+ channels and nitrergic responses in the murine colon.

@article{Park2005SulfurcontainingAA,
  title={Sulfur-containing amino acids block stretch-dependent K+ channels and nitrergic responses in the murine colon.},
  author={Kyu Joo Park and Salah A Baker and Sang Yun Cho and Kenton M. Sanders and Sang Don Koh},
  journal={British journal of pharmacology},
  year={2005},
  volume={144 8},
  pages={
          1126-37
        }
}
1. Efforts to determine the role of stretch-dependent K(+) (SDK) channels in enteric inhibitory neural responses in gastrointestinal muscles are difficult due to a lack of blocking drugs for SDK channels. 2. SDK channels are blocked by sulfur-containing amino acids. These compounds reduced the open probability of SDK channels in on and off-cell patches of murine colonic myocytes. L-Methionine was the most selective and had little or no effect on other known K(+) conductances in colonic myocytes… CONTINUE READING
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