Sulfotransferase-mediated activation of mutagens studied using heterologous expression systems.

@article{Glatt1998SulfotransferasemediatedAO,
  title={Sulfotransferase-mediated activation of mutagens studied using heterologous expression systems.},
  author={Hans Rudolf Glatt and Ingrid Bartsch and Sandra Christoph and Michael W.H. Coughtrie and Charles N. Falany and Michael Hagen and Robert Landsiedel and Ulrike Pabel and David H Phillips and Albrecht Seidel and Yasushi Yamazoe},
  journal={Chemico-biological interactions},
  year={1998},
  volume={109 1-3},
  pages={
          195-219
        }
}
Sulfation is a common final step in the biotransformation of xenobiotics and is traditionally associated with inactivation. However, the sulfate group is electron-withdrawing and may be cleaved off heterolytically in some molecules leading to electrophilic cations which may form adducts with DNA and other important cellular structures. Since endogenous sulfotransferases do not appear to be expressed in indicator cells of standard mutagenicity tests, rat and human sulfotransferases have been… CONTINUE READING

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