Sulforaphene suppresses growth of colon cancer-derived tumors via induction of glutathione depletion and microtubule depolymerization.

@article{Byun2016SulforapheneSG,
  title={Sulforaphene suppresses growth of colon cancer-derived tumors via induction of glutathione depletion and microtubule depolymerization.},
  author={Sanguine Byun and Seung Ho Shin and Jiman Park and Semi Lim and Eunjung Lee and Chaeyoon Lee and Dongeun Sung and Lee Farrand and Seoung Rak Lee and Ki Hyun Kim and Ziming Dong and Sam W. Lee and Ki Won Lee},
  journal={Molecular nutrition & food research},
  year={2016},
  volume={60 5},
  pages={1068-78}
}
SCOPE Cruciferous vegetables harbor a number of isothiocyanates that have been recognized for their cancer-related properties. Out of these, sulforaphene (a naturally occurring derivative of sulforaphane) has received little attention in studies of colon cancer and its mechanism of action remains to be elucidated. METHODS AND RESULTS We observed that sulforaphene inhibited growth of human colon cancer cell lines HCT116, HT-29, KM12, SNU-1040, and DLD-1, while exhibiting negligible toxicity… CONTINUE READING