Sulforaphane suppresses oligomerization of TLR4 in a thiol-dependent manner.

  title={Sulforaphane suppresses oligomerization of TLR4 in a thiol-dependent manner.},
  author={Hyung Sun Youn and Yoon Sun Kim and Zee Yong Park and So Young Kim and Na Young Choi and Sun Myung Joung and Jung Ae Seo and Kyung-Min Lim and Mi-Kyoung Kwak and Daniel H. Hwang and Joo Young Lee},
  journal={Journal of immunology},
  volume={184 1},
TLRs are pattern recognition receptors that detect invading microorganisms and nonmicrobial endogenous molecules to trigger immune and inflammatory responses during host defense and tissue repair. TLR activity is closely linked to the risk of many inflammatory diseases and immune disorders. Therefore, TLR signaling pathways can provide efficient therapeutic targets for chronic diseases. Sulforaphane (SFN), an isothiocyanate, has been well known for its anti-inflammatory activities. In this… CONTINUE READING
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