Sulforaphane rescues memory dysfunction and synaptic and mitochondrial alterations induced by brain iron accumulation.

Abstract

Iron overload contributes to the development of neurodegeneration and the exacerbation of normal apoptosis rates, largely due to its participation in the Fenton reaction and production of reactive oxygen species (ROS). Mitochondria constitute the major intracellular source of ROS and the main target of attack by free radicals. They are dynamic organelles… (More)
DOI: 10.1016/j.neuroscience.2015.06.025

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Cite this paper

@article{Lavich2015SulforaphaneRM, title={Sulforaphane rescues memory dysfunction and synaptic and mitochondrial alterations induced by brain iron accumulation.}, author={I C Lavich and Bet{\^a}nia Souza de Freitas and Luiza Wilges Kist and Let{\'i}cia Ferreira Falavigna and Vin{\'i}cius Ayub Darg{\'e}l and Luiza Machado K{\"o}be and Cristiano Aguzzoli and B Piffero and Pierre Florian and Maur{\'i}cio Reis Bogo and M N M de Lima and Nadja Schr{\"o}der}, journal={Neuroscience}, year={2015}, volume={301}, pages={542-52} }