Sulforaphane protects kidneys against ischemia-reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme.

@article{Yoon2008SulforaphanePK,
  title={Sulforaphane protects kidneys against ischemia-reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme.},
  author={Ha-Yong Yoon and Nam-In Kang and Hern-Ku Lee and Kyu Yun Jang and Jin-Woo Park and Byung-Hyun Park},
  journal={Biochemical pharmacology},
  year={2008},
  volume={75 11},
  pages={
          2214-23
        }
}
Reactive oxygen species are important mediators that exert a toxic effect during ischemia-reperfusion injury of various organs. Sulforaphane, which is a naturally occurring isothiocyanate that is present in cruciferous vegetables such as broccoli, is known to be an indirect antioxidant that acts by inducing Nrf2-dependent phase 2 enzymes. Phase 2 enzymes such as heme oxygenase-1, NAD(P)H: quinone oxidoreductase 1, glutathione reductase, and glutathione peroxidase participate in adaptive and… CONTINUE READING

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