Sulforaphane protects from T cell-mediated autoimmune disease by inhibition of IL-23 and IL-12 in dendritic cells.

@article{Geisel2014SulforaphanePF,
  title={Sulforaphane protects from T cell-mediated autoimmune disease by inhibition of IL-23 and IL-12 in dendritic cells.},
  author={Julia Geisel and J{\"u}rgen Br{\"u}ck and Ivana Glocova and Katja Dengler and Tobias Sinnberg and Oliver Rothfuss and Michael Walter and Klaus Schulze-Osthoff and Martin Roecken and Kamran Ghoreschi},
  journal={Journal of immunology},
  year={2014},
  volume={192 8},
  pages={3530-9}
}
Sulforaphane (SFN), an isothiocyanate, is part of an important group of naturally occurring small molecules with anti-inflammatory properties. The published reports are best conceivable with an inhibition of T cell function, but the mode of action remains unknown. We therefore analyzed the effect of SFN on T cell-mediated autoimmune disease. Feeding mice with SFN protected from severe experimental autoimmune encephalomyelitis. Disease amelioration was associated with reduced IL-17 and IFN… CONTINUE READING
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