Sulforaphane inhibits invasion by phosphorylating ERK1/2 to regulate E-cadherin and CD44v6 in human prostate cancer DU145 cells.

@article{Peng2015SulforaphaneII,
  title={Sulforaphane inhibits invasion by phosphorylating ERK1/2 to regulate E-cadherin and CD44v6 in human prostate cancer DU145 cells.},
  author={Xiaohui Peng and Yan Zhou and Hua Tian and Gaoxiang Yang and Chunliu Li and Yang Geng and Sai Wu and Wei Wu},
  journal={Oncology reports},
  year={2015},
  volume={34 3},
  pages={1565-72}
}
Advanced prostate cancer has highly invasive potential, which may lead to metastasis associated with poor prognosis. Sulforaphane (SFN), abundant in cruciferous vegetables, exhibited effective resistance to carcinogenesis in a variety of tumors. The aim of the present study was to investigate whether SFN inhibited invasion in human prostate cancer cells via sustained activation of ERK1/2 and downstream signaling by an invasion assay, gelatin zymography and western blot analysis. The results… CONTINUE READING

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