Sulforaphane induces SLPI secretion in the nasal mucosa.

  title={Sulforaphane induces SLPI secretion in the nasal mucosa.},
  author={Megan Meyer and Matthew J. Kesic and John Clarke and Emily E. Ho and Rosalia C. M. Simmen and David D{\'i}az-S{\'a}nchez and Terry L Noah and Ilona Jaspers},
  journal={Respiratory medicine},
  volume={107 3},
Cells lining the respiratory tract are equipped with mechanisms that dampen the effects of oxidative stress. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a mediator involved in regulating oxidative stress. Recent data indicate Nrf2 also controls expression of secretory leukocyte protease inhibitor (SLPI). Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, enhances Nrf2 activity. Therefore, we hypothesized that SFN supplementation induces SLPI secretion in the nasal… CONTINUE READING
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