Sulforaphane induces DNA single strand breaks in cultured human cells.

@article{Sestili2010SulforaphaneID,
  title={Sulforaphane induces DNA single strand breaks in cultured human cells.},
  author={Piero Sestili and Marco Paolillo and Monia Lenzi and Evelin Colombo and Luciana Vallorani and Lucia Casadei and Chiara Martinelli and Carmela Fimognari},
  journal={Mutation research},
  year={2010},
  volume={689 1-2},
  pages={
          65-73
        }
}
Sulforaphane (SFR), an isothiocyanate from cruciferous vegetables, possesses growth-inhibiting and apoptosis-inducing activities in cancer cell lines. Recently, SFR has been shown to promote the mitochondrial formation of reactive oxygen species (ROS) in human cancer cell lines. The present study was undertaken to see whether SFR-derived ROS might cause DNA damage in cultured human cells, namely T limphoblastoid Jurkat and human umbilical vein endothelial cells (HUVEC). 1-3 h treatments with 10… CONTINUE READING

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