Sulforaphane increases drug-mediated cytotoxicity toward cancer stem-like cells of pancreas and prostate.

@article{Kallifatidis2011SulforaphaneID,
  title={Sulforaphane increases drug-mediated cytotoxicity toward cancer stem-like cells of pancreas and prostate.},
  author={Georgios Kallifatidis and Sabrina Labsch and Vanessa Rausch and Juergen Mattern and Jury Gladkich and Gerhard Moldenhauer and Markus W. B{\"u}chler and Alexei V. Salnikov and Ingrid Herr},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2011},
  volume={19 1},
  pages={188-95}
}
Despite intense efforts to develop treatments against pancreatic cancer, agents that cure this highly resistant and metastasizing disease are not available. Considerable attention has focused on broccoli compound sulforaphane (SF), which is suggested as combination therapy for targeting of pancreatic cancer stem cells (CSCs). However, there are concerns that antioxidative properties of SF may interfere with cytotoxic drugs-as suggested, e.g., for vitamins. Therefore we investigated a… CONTINUE READING
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