Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells.

@article{Matsui2006SulforaphaneET,
  title={Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells.},
  author={Taka-aki Matsui and Yoshihiro Sowa and Tatsushi Yoshida and Hiroaki Murata and Mano Horinaka and Miki Wakada and Ryoko Nakanishi and Tomoya Sakabe and Toshikazu Kubo and Toshiyuki Sakai},
  journal={Carcinogenesis},
  year={2006},
  volume={27 9},
  pages={1768-77}
}
Sulforaphane (SFN), a naturally occurring isothiocyanate, is an attractive agent because of its potent anticancer effects. SFN suppresses the proliferation of various cancer cells in vitro and in vivo. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is also one of the most promising candidates for cancer therapeutics owing to its ability to selectively induce apoptosis in tumor cells. In this study, we report that SFN enhances TRAIL-induced apoptosis in human osteosarcoma cells… CONTINUE READING