Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation
@article{Bai2015SulforaphanePA, title={Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation}, author={Yang Bai and Xiaolu Wang and Song Zhao and Chun-ye Ma and Jiuwei Cui and Yang Zheng}, journal={Oxidative Medicine and Cellular Longevity}, year={2015}, volume={2015}, url={https://api.semanticscholar.org/CorpusID:979207} }
The evidence from clinical studies and animal experiments relating to the potential mechanisms by which SFN modulates Nrf2 activation and protects against CVD are summarized.
161 Citations
Concerted redox modulation by sulforaphane alleviates diabetes and cardiometabolic syndrome.
- 2018
Chemistry, Environmental Science
A review on herbal Nrf2 activators with preclinical evidence in cardiovascular diseases
- 2021
Medicine, Environmental Science
The activation of Nrf2 pathway is highlighted as a budding therapeutic option for the prevention and treatment of CVDs, which needs further investigation and validation in the clinical settings.
Therapeutic Effects of Nrf2 Activation by Bardoxolone Methyl in Chronic Heart Failure
- 2019
Medicine, Environmental Science
Systemic activation of Nrf2 and antioxidant protein signaling by bardoxolone methyl may have beneficial effects on cardiac function and result in improvements by enhancing antioxidant enzyme expression and attenuating myocardial inflammation.
The Role of Natural Products in Targeting Cardiovascular Diseases via Nrf2 Pathway: Novel Molecular Mechanisms and Therapeutic Approaches
- 2018
Medicine, Environmental Science
The beneficial effects of using natural bioactive compounds as a promising therapeutic approach for the prevention and treatment of CVDs are reviewed.
Nrf2 at the heart of oxidative stress and cardiac protection.
- 2018
Biology, Environmental Science
Multiple lines of evidence presented here support the potential of dialing up the Nrf2 pathway for cardiac protection in the clinic, including removal of Keap1 by autophagy due to p62/SQSTM1 binding, inhibition of βTrCP or Synoviolin/Hrd1-mediated ubiquitination of NRF2, and de novo Nrf1 protein translation.
Sulforaphane induces neurovascular protection against a systemic inflammatory challenge via both Nrf2-dependent and independent pathways.
- 2016
Environmental Science, Medicine
Effects of sulforaphane on the oxidative response, apoptosis, and the transcriptional profile of human stomach mucosa cells in vitro.
- 2020
Medicine, Environmental Science
Activation of the Nrf-2/HO-1 signalling axis can alleviate metabolic syndrome in cardiovascular disease
- 2023
Medicine, Environmental Science
A review of the literature on Nrf2/HO-1 and its role in metabolic disease syndrome and CVD provides an overview of the literature on Nrf2/HO-1 and its role in metabolic disease syndrome and CVD.
Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies
- 2024
Medicine, Chemistry
SFN’s ability to activate Nrf2, a transcription factor regulating oxidative stress and inflammation in cells, is a primary mechanism behind its anticancerogenic and antidiabetic effects and its antioxidant, anti-inflammatory, and anti-apoptotic properties are suggested to provide beneficial effects against neurodegenerative diseases.
91 References
Modulation of phase II enzymes by sulforaphane: implications for its cardioprotective potential.
- 2009
Medicine
The potential cardioprotective action of sulforaphane was confirmed by the decrease in intracellular reactive oxygen species production, the increase in cell viability, and the decreases in DNA fragmentation after long-term treatment accompanied by the induction of antioxidants and phase II enzymes in cardiomyocytes.
Protective effect of sulforaphane against oxidative stress: recent advances.
- 2012
Medicine, Environmental Science
Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane.
- 2013
Biology, Environmental Science
Results from these clinical trials indicate that interventions with well characterized preparations of broccoli sprouts may enhance the detoxication of aflatoxins and air-borne toxins, which may in turn attenuate their associated health risks, including cancer, in exposed individuals.
Sulforaphane prevention of diabetes-induced aortic damage was associated with the up-regulation of Nrf2 and its down-stream antioxidants
- 2012
Environmental Science, Medicine
It is suggested that diabetes-induced aortic fibrosis, inflammation, and oxidative damage can be prevented by SFN and the aortIC protection from diabetes bySFN was associated with the up-regulation of Nrf2 and its downstream antioxidants.
The emerging role of redox-sensitive Nrf2-Keap1 pathway in diabetes.
- 2015
Medicine, Environmental Science
The pathological roles of environmental and redox stresses in cardiovascular diseases
- 2012
Environmental Science, Medicine
This review focuses on the pathological roles of environmental and redox stresses in cardiovascular diseases, especially severe cardiac dysfunction and the transition from compensated hypertrophy to heart failure.
Repeated transient sulforaphane stimulation in astrocytes leads to prolonged Nrf2-mediated gene expression and protection from superoxide-induced damage
- 2011
Biology, Environmental Science
Translational studies of A20 in atherosclerosis and cardiovascular disease.
- 2014
Medicine, Biology
The role of the NF- kappaB-regulated, yet potent NF-kappaB inhibitory and anti-inflammatory gene A20/TNFAIP3 in atherogenesis is reviewed, and the potential use of its atheroprotective properties for the prevention and treatment of cardiovascular diseases is highlighted.
Nrf2 and NF-κB modulation by sulforaphane counteracts multiple manifestations of diabetic neuropathy in rats and high glucose-induced changes.
- 2011
Environmental Science, Medicine
Evidence that sulforaphane is effective in reversing the various deficits in experimental diabetic neuropathy is provided and the defensive role of Nrf2 in neurons under conditions of oxidative stress is supported and suggests that the NF-κB pathway is an important modulator of inflammatory damage in diabetic neuroopathy.