Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells.

@article{GametPayrastre2000SulforaphaneAN,
  title={Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells.},
  author={Laurence Gamet-Payrastre and Peng Li and Solange Lumeau and Georges Cassar and Mich{\`e}le A. Dupont and Sylvie Chevolleau and Nicole Gasc and Jacques E. Tulliez and François Terc{\'e}},
  journal={Cancer research},
  year={2000},
  volume={60 5},
  pages={1426-33}
}
Sulforaphane is an isothiocyanate that is present naturally in widely consumed vegetables and has a particularly high concentration in broccoli. This compound has been shown to block the formation of tumors initiated by chemicals in the rat. Although sulforaphane has been proposed to modulate the metabolism of carcinogens, its mechanism of action remains poorly understood. We have previously demonstrated that sulforaphane inhibits the reinitiation of growth and decreases the cellular viability… CONTINUE READING
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