Sulfonylurea treatment of type 2 diabetes mellitus: focus on glimepiride.

@article{Korytkowski2004SulfonylureaTO,
  title={Sulfonylurea treatment of type 2 diabetes mellitus: focus on glimepiride.},
  author={Mary T Korytkowski},
  journal={Pharmacotherapy},
  year={2004},
  volume={24 5},
  pages={606-20}
}
Sulfonylureas, which have evolved through two generations since their introduction nearly 50 years ago, remain the most frequently prescribed oral agents for treatment of patients with type 2 diabetes mellitus. Glyburide, glipizide, and glimepiride, the newest sulfonylureas, are as effective at lowering plasma glucose concentrations as first-generation agents but are more potent, better tolerated, and associated with a lower risk of adverse effects. Differences in their binding affinity to the… CONTINUE READING

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