Sulfonylurea treatment of type 2 diabetes mellitus: focus on glimepiride.

  title={Sulfonylurea treatment of type 2 diabetes mellitus: focus on glimepiride.},
  author={Mary T Korytkowski},
  volume={24 5},
Sulfonylureas, which have evolved through two generations since their introduction nearly 50 years ago, remain the most frequently prescribed oral agents for treatment of patients with type 2 diabetes mellitus. Glyburide, glipizide, and glimepiride, the newest sulfonylureas, are as effective at lowering plasma glucose concentrations as first-generation agents but are more potent, better tolerated, and associated with a lower risk of adverse effects. Differences in their binding affinity to the… CONTINUE READING


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