Sulfonylurea-mediated stimulation of insulin exocytosis via an ATP-sensitive K+ channel-independent action.

@article{Renstrm2002SulfonylureamediatedSO,
  title={Sulfonylurea-mediated stimulation of insulin exocytosis via an ATP-sensitive K+ channel-independent action.},
  author={Erik Renstr{\"o}m and Sebastian Barg and Frank Th{\'e}venod and Patrik Rorsman},
  journal={Diabetes},
  year={2002},
  volume={51 Suppl 1},
  pages={S33-6}
}
Several reports indicate that hypoglycemic sulfonylureas augment Ca(2+)-dependent insulin secretion via mechanisms other than inhibition of the ATP-sensitive K(+) channel. The effect involves a 65-kd protein in the granule membrane and culminates in intragranular acidification. Lowering of granule pH is necessary for the insulin granule to gain release competence. Proton pumping into the granule is driven by a v-type H(+)-ATPase, but requires simultaneous Cl(-) uptake into the granule via… CONTINUE READING
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