Sulfonylurea Receptor 1 in the Germinal Matrix of Premature Infants

@article{Simard2008SulfonylureaR1,
  title={Sulfonylurea Receptor 1 in the Germinal Matrix of Premature Infants},
  author={J. Marc Simard and R Castellani and Svetlana Ivanova and Michael T. Koltz and Volodymyr Gerzanich},
  journal={Pediatric Research},
  year={2008},
  volume={64},
  pages={648-652}
}
Germinal matrix (GM) hemorrhage (GMH) is a major cause of mortality and of life-long morbidity from cerebral palsy. GMH is typically preceded by hypoxic/ischemic events and is believed to arise from rupture of weakened veins in the GM. In the CNS, hypoxia/ischemia up-regulate sulfonylurea receptor 1 (SUR1)-regulated NCCa-ATP channels in microvascular endothelium, with channel activation by depletion of ATP being responsible for progressive secondary hemorrhage. We hypothesized that this channel… CONTINUE READING

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