Sulfonyl fluorides as privileged warheads in chemical biology

Abstract

Sulfonyl fluoride electrophiles have found significant utility as reactive probes in chemical biology and molecular pharmacology. As warheads they possess the right balance of biocompatibility (including aqueous stability) and protein reactivity. Their functionality is privileged in this regard as they are known to modify not only reactive serines… (More)
DOI: 10.1039/c5sc00408j

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Cite this paper

@inproceedings{Narayanan2015SulfonylFA, title={Sulfonyl fluorides as privileged warheads in chemical biology}, author={Arjun Narayanan and Lyn H Jones}, booktitle={Chemical science}, year={2015} }