Sulfonyl Fluoride Analogues as Activity‐Based Probes for Serine Proteases

@article{Shannon2012SulfonylFA,
  title={Sulfonyl Fluoride Analogues as Activity‐Based Probes for Serine Proteases},
  author={D. A. Shannon and C. Gu and Christopher J. McLaughlin and M. Kaiser and R. V. D. van der Hoorn and E. Weerapana},
  journal={ChemBioChem},
  year={2012},
  volume={13}
}
Enriched with fluoride: To expand on the available tools to interrogate proteases, we explored sulfonyl fluorides as activity-based probes. An alkyne-tagged sulfonyl fluoride covalently modifies members of the S1 family of serine proteases. By applying click chemistry, avidin enrichment and mass spectrometry, we can enrich and identify active endogenous serine proteases from a complex proteome. 
Novel activity-based probes for serine proteases
Phosphoramidates as Novel Activity‐Based Probes for Serine Proteases
Probing functional tyrosines.
Rational targeting of active-site tyrosine residues using sulfonyl fluoride probes.
Chemical proteomics with sulfonyl fluoride probes reveals selective labeling of functional tyrosines in glutathione transferases.
Covalent protein modification: the current landscape of residue-specific electrophiles.
Investigating the proteome reactivity and selectivity of aryl halides.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 32 REFERENCES
Using peptidyl aldehydes in activity-based proteomics.
Glycine Fluoromethylketones as SENP‐Specific Activity Based Probes
Activity-based probes that target diverse cysteine protease families
In-cell Selectivity Profiling of Serine Protease Inhibitors by Activity-based Proteomics*S
Activity-based probes as a tool for functional proteomic analysis of proteases
...
1
2
3
4
...