Sulfonation of papain-treated chitosan and its mechanism for anticoagulant activity.

@article{Suwan2009SulfonationOP,
  title={Sulfonation of papain-treated chitosan and its mechanism for anticoagulant activity.},
  author={Jiraporn Suwan and Zhenqing Zhang and Boyangzi Li and Preeyanat Vongchan and Puttinan Meepowpan and Fuming Zhang and Shaker A. Mousa and Bhusana Premanode and Prachya Kongtawelert and Robert J. Linhardt},
  journal={Carbohydrate research},
  year={2009},
  volume={344 10},
  pages={1190-6}
}
The novel low-molecular-weight chitosan polysulfate (MW 5120-26,200 Da) was prepared using the depolymerization of chitosan with papain (EC. 3.4.22.2). The sulfonation of depolymerized products was performed using chlorosulfonic acid in N,N-dimethylformamide under semi-heterogeneous conditions. The structures of the products were characterized by FTIR, (13)C NMR, and (1)H NMR (1D, 2D NMR) spectroscopy. The present study sheds light on the mechanism of anticoagulant activity of chitosan… CONTINUE READING
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