Sulfonamide-metal complexes endowed with potent anti-Trypanosoma cruzi activity.

  title={Sulfonamide-metal complexes endowed with potent anti-Trypanosoma cruzi activity.},
  author={Zahid Hussain Chohan and Marcelo Zaldini Hernandes and Fabr{\'i}cio Ronil Sensato and Diogo Rodrigo de Magalh{\~a}es Moreira and Val{\'e}ria Rěgo Alves Pereira and Juliana Kelle de Andrade Lemoine Neves and Andresa Pereira de Oliveira and Beatriz Coutinho de Oliveira and Ana Cristina Lima Leite},
  journal={Journal of enzyme inhibition and medicinal chemistry},
  volume={29 2},
In this article, we describe that mononuclear complexes composed of (5-chloro-2-hydroxybenzylidene)aminobenzenesulfonamides (L1-3) of general formula (L2(M)2H2O, where M is Co, Cu, Zn, Ni or Mn) reduced epimastigote proliferation and were found cidal for trypomastigotes of Trypanosoma cruzi Y strain. Complexes C5 and C11 have IC50 of 2.7 ± 0.27 and 4.8 ± 0.47 µM, respectively, for trypomastigotes, when the positive control Nifurtimox, which is also an approved drug for Chagas disease, showed… CONTINUE READING
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