Sulfonamide and trimethoprim concentrations in human serum and skin blister fluid.

@article{Bruun1981SulfonamideAT,
  title={Sulfonamide and trimethoprim concentrations in human serum and skin blister fluid.},
  author={Johan Nikolai Bruun and N Ostby and Jan Erik Bredesen and Peter B Kierulf and PerKnutM. Lunde},
  journal={Antimicrobial agents and chemotherapy},
  year={1981},
  volume={19 1},
  pages={
          82-5
        }
}
Various sulfonamides and trimethoprim were given orally twice a day to healthy volunteers. The drug concentrations in serum and tissue fluid from skin blisters were determined concomitantly. Maximal serum concentrations were obtained after 1 to 3 h. Absorption of sulfacarbamide and sulfadimidine was more rapid than for sulfadiazine, sulfamethoxazole, and trimethoprim. The penetration to blister fluid was delayed and maximal concentrations were usually reached after 4 to 8 h. The highest… CONTINUE READING

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