Sulfiredoxin protects mice from lipopolysaccharide-induced endotoxic shock.

  title={Sulfiredoxin protects mice from lipopolysaccharide-induced endotoxic shock.},
  author={Anne-Ga{\"e}lle Planson and Ga{\"e}l Palais and Kahina Abbas and Matthieu G{\'e}rard and Linhdavanh Couvelard and Agn{\`e}s Delaunay and Sylvain Baulande and J. -C. Drapier and Michel B. Toledano},
  journal={Antioxidants & redox signaling},
  volume={14 11},
Peroxiredoxins constitute a major family of cysteine-based peroxide-scavenging enzymes. They carry an intriguing redox switch by undergoing substrate-mediated inactivation via overoxidation of their catalytic cysteine to the sulfinic acid form that is reverted by reduction catalyzed by the sulfinic acid reductase sulfiredoxin (Srx). The biological significance of such inactivation is not understood, nor is the function of Srx1. To address this question, we generated a mouse line with a null… CONTINUE READING
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