Sulfidopeptide leukotrienes mediate acrolein-induced bronchial hyperresponsiveness.

  title={Sulfidopeptide leukotrienes mediate acrolein-induced bronchial hyperresponsiveness.},
  author={George D. Leikauf and Craig A. Doupnik and L M Leming and Huan-Yun Wey},
  journal={Journal of applied physiology},
  volume={66 4},
The sulfidopeptide leukotrienes are bronchoconstrictive lipid mediators thought to have an important role in the pathophysiology of asthma. The objective of this study was to determine if treatment with a leukotriene receptor antagonist and 5-lipoxygenase inhibitors could diminish acrolein-induced bronchial hyperresponsiveness and to determine whether leukotriene (LT) C4 generation is augmented by acrolein exposure. Guinea pigs (groups of 6-7) were exposed to 1.3 ppm acrolein for 2 h and… CONTINUE READING