Sulfide inhibition of and metabolism by cytochrome c oxidase.

  title={Sulfide inhibition of and metabolism by cytochrome c oxidase.},
  author={P. Nicholls and D. Marshall and C. Cooper and M. Wilson},
  journal={Biochemical Society transactions},
  volume={41 5},
  • P. Nicholls, D. Marshall, +1 author M. Wilson
  • Published 2013
  • Chemistry, Medicine
  • Biochemical Society transactions
  • Hydrogen sulfide (H2S), a classic cytochrome c oxidase inhibitor, is also an in vitro oxidase substrate and an in vivo candidate hormonal ('gasotransmitter') species affecting sleep and hibernation. H2S, nitric oxide (NO) and carbon monoxide (CO) share some common features. All are low-molecular-mass physiological effectors and also oxidase inhibitors, capable of binding more than one enzyme site, and each is an oxidizable 'substrate'. The oxidase oxidizes CO to CO2, NO to nitrite and sulfide… CONTINUE READING
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    • 26
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    • 144
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    • 42
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    • L. Petersen
    • Chemistry, Medicine
    • Biochimica et biophysica acta
    • 1977
    • 141
    Studies on Cytochrome Oxidase
    • 20
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