Sulfide-detoxifying enzymes in the human colon are decreased in cancer and upregulated in differentiation.

@article{Ramasamy2006SulfidedetoxifyingEI,
  title={Sulfide-detoxifying enzymes in the human colon are decreased in cancer and upregulated in differentiation.},
  author={Sharmaine Ramasamy and S Singh and Philippe Tanière and Michael J. S. Langman and Margaret C. Eggo},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2006},
  volume={291 2},
  pages={
          G288-96
        }
}
  • S. Ramasamy, S. Singh, +2 authors M. Eggo
  • Published 2006
  • Biology, Medicine
  • American journal of physiology. Gastrointestinal and liver physiology
H2S is highly toxic and selectively inhibits butyrate oxidation in colonocytes. Ineffective detoxification may result in mucosal insult, inflammation, and ultimately in colorectal cancer (CRC). Rhodanese can detoxify H2S and is comprised of two isoenzymes: thiosulfate sulfurtransferase (TST) and mercaptopyruvate sulfurtransferase (MST). Using specific antisera to discriminate TST from MST, we found that only TST could detoxify H2S. In sections of normal colon, both enzymes were located on the… Expand
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