Sulfhydryl oxidation reduces hippocampal susceptibility to hypoxia-induced spreading depression by activating BK channels.

@article{Hepp2005SulfhydrylOR,
  title={Sulfhydryl oxidation reduces hippocampal susceptibility to hypoxia-induced spreading depression by activating BK channels.},
  author={Sebastian Hepp and Florian J. Gerich and Michael M{\"u}ller},
  journal={Journal of neurophysiology},
  year={2005},
  volume={94 2},
  pages={1091-103}
}
The cytosolic redox status modulates ion channels and receptors by oxidizing/reducing their sulfhydryl (SH) groups. We therefore analyzed to what degree SH modulation affects hippocampal susceptibility to hypoxia. In rat hippocampal slices, severe hypoxia caused a massive depolarization of CA1 neurons and a negative shift of the extracellular DC potential… CONTINUE READING