Sulfation patterns of glycosaminoglycans encode molecular recognition and activity.

@article{Gama2006SulfationPO,
  title={Sulfation patterns of glycosaminoglycans encode molecular recognition and activity.},
  author={Cristal I Gama and Sarah E. Tully and Naoki Sotogaku and Peter M. Clark and Manish Rawat and Nagarajan Vaidehi and William A. Goddard and Akinori Nishi and Linda C Hsieh-Wilson},
  journal={Nature chemical biology},
  year={2006},
  volume={2 9},
  pages={467-73}
}
Although glycosaminoglycans contribute to diverse physiological processes, an understanding of their molecular mechanisms has been hampered by the inability to access homogeneous glycosaminoglycan structures. Here, we assembled well-defined chondroitin sulfate oligosaccharides using a convergent, synthetic approach that permits installation of sulfate groups at precise positions along the carbohydrate backbone. Using these defined structures, we demonstrate that specific sulfation motifs… CONTINUE READING