Sulfation of thyroid hormone and dopamine during human development: ontogeny of phenol sulfotransferases and arylsulfatase in liver, lung, and brain.

@article{Richard2001SulfationOT,
  title={Sulfation of thyroid hormone and dopamine during human development: ontogeny of phenol sulfotransferases and arylsulfatase in liver, lung, and brain.},
  author={Kerry Richard and Robert Hume and Ellen Kaptein and Emma L Stanley and Theo J. Visser and Michael W. H. Coughtrie},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2001},
  volume={86 6},
  pages={2734-42}
}
Sulfation is an important mechanism for regulating the biological activity of numerous hormones and neurotransmitters in man. Here we have investigated the ontogeny of sulfotransferases (SULT) and sulfatase (ARS) involved in the metabolism of thyroid hormone and dopamine. SULT1A1 enzyme activity was lower in postnatal liver and lung than in fetal tissues. Hepatic SULT1A3 (dopamine) was expressed at high levels early in development, but decreased substantially in late fetal/early neonatal liver… CONTINUE READING
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