Sulfation of genistein alters its antioxidant properties and its effect on platelet aggregation and monocyte and endothelial function.

@article{Rimbach2004SulfationOG,
  title={Sulfation of genistein alters its antioxidant properties and its effect on platelet aggregation and monocyte and endothelial function.},
  author={Gerald H. Rimbach and Peter D. Weinberg and Sonia de Pascual-Teresa and M. Dolores Garc{\'i}a Alonso and Ben A Ewins and Rufus Paul Turner and Anne Marie Minihane and Nigel P. Botting and Brian Fairley and Seiichi Matsugo and Yuzo Uchida and Aedin Cassidy},
  journal={Biochimica et biophysica acta},
  year={2004},
  volume={1670 3},
  pages={
          229-37
        }
}
Soy isoflavones have been extensively studied because of their possible benefits to human health. Genistein, the major isoflavone aglycone, has received most attention; however, it undergoes extensive metabolism (e.g. conjugation with sulfuric acid) in the gut and liver, which may affect its biological properties. This study investigated the antioxidant activity and free radical-scavenging properties of genistein, genistein-4'-sulfate and genistein-4'-7-disulfate as well as their effect on… CONTINUE READING
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