Sulfation of estrone and 17 beta-estradiol in human liver. Catalysis by thermostable phenol sulfotransferase and by dehydroepiandrosterone sulfotransferase.

@article{Hernndez1992SulfationOE,
  title={Sulfation of estrone and 17 beta-estradiol in human liver. Catalysis by thermostable phenol sulfotransferase and by dehydroepiandrosterone sulfotransferase.},
  author={J. S{\'a}nchez Hern{\'a}ndez and R William G Watson and Thomas Charles Wood and Richard M. Weinshilboum},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1992},
  volume={20 3},
  pages={413-22}
}
Sulfation is a major pathway in humans for the biotransformation of estrogens. However, the nature of the enzymes that catalyze the sulfation of estrone (E1) and 17 beta-estradiol (E2) in human liver is unclear. Human liver contains at least three well-characterized cytoplasmic sulfotransferases, the thermostable (TS) and thermolabile (TL) forms of phenol… CONTINUE READING