Sulfation of chondroitin sulfate in human articular cartilage. The effect of age, topographical position, and zone of cartilage on tissue composition.

@article{Bayliss1999SulfationOC,
  title={Sulfation of chondroitin sulfate in human articular cartilage. The effect of age, topographical position, and zone of cartilage on tissue composition.},
  author={Michael T. Bayliss and David J. Osborne and Sandra M. Woodhouse and Catherine Davidson},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 22},
  pages={15892-900}
}
The chondroitin ABC lyase digestion products of normal human femoral condyle articular cartilage and of purified aggrecan were analyzed for their mono- and nonsulfated disaccharide composition. Changes in the total tissue chemistry were most pronounced during the period from birth to 20 years of age, when the -[GlcAbeta,3GalNAc6]- disaccharide content increased from approximately 50% to 85% of the total disaccharide content and there was a concomitant decrease in the content of the 4-sulfated… CONTINUE READING

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