Sulfation of Tyrleso of Human Blood Coagulation Factor VI 11 Is Essential for the Interaction of Factor VI 11 with von Willebrand Factor *

  • A. van MourikQ
  • Published 2001

Abstract

The acidic region of the Factor VI11 light chain was studied with regard to structural requirements for the formation of a functional von Willebrand factor (vWF)binding site. Factor VI11 mutants lacking the B domain, with additional deletions and an amino acid replacement within the sequence 1649-1689 were constructed using site-directed mutagenesis and… (More)

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